Roger Federer played wonderfully to request a third straight win over Rafael Nadal for the first time in his career, he reaches the last eight in Indian Wells.
The Swiss, won 6-2, 6-3 to follow up his Australian Open final win over the Spaniard two months ago.
He will next face Australia's Nick Kyrgios, who upset world number two Novak Djokovic 6-4 7-6 (7-3).
Svetlana Kuznetsova was the first player through the women's.
The eighth seed saw off fellow Russian Anastasia Pavlyuchenkova 6-3 6-2 and will meet Czech third seed Karolina Pliskova after she hit Spain's French Open champion Garbine Muguruza 7-6 7-6.
In the pair's 36th meeting and first before the quarter-finals of a meeting since their beginning meeting in Miami 13 years ago - Federer notched his 13th victory and third in a row.
Nadal, 30, had built his coup against Federer over the years on attacking the Swiss player's backhand, but Federer become his weaker wing into a weapon in the Australian Open final, and if anything was even more hostile in Indian Wells.
Federer crunched six backhand winners to not one from Nadal as he played a flawless opening set, taking it in a little over half an hour.
Nadal might have expected to profit from an external markedly slower than that in Melbourne but it did nothing to curb Federer's aggressive purpose.
Another early break in the second set had Federer within sight of the finish line and he competed through with four breaks of serve to not one to win in 68 minutes.
"I did very well today, I'm so pleased I'm able to step into the court and play super aggressive," said Federer.
"It's a nice feeling to win the last three sad the four-time Indian Wells champion. "But most importantly, I won Australia. That was big for me.
Kyrgios, 21, gave further proof that he is now a force to be reckoned with as he blunted the Djokovic return game with another magnificent serving performance.
Djokovic, 29, was on a 19-match winning streak in the Californian desert, and bidding for a fourth in the succession title, but Kyrgios took their personal head-to-head to 2-0 as he repeated his victory in their first meeting in Acapulco 12 days ago.
The Australian took the only service break of the match in the opening game, which proved enough to take the first set, and clinched the second after racing into a 3-0 tie-break lead.
Djokovic commented the Australian's serve, adding: "Nick, again, as he did in Acapulco, worked so well. I just wasn't managing to get a lot of balls back on his serve, first and second, as well. That's what made a difference."
Japan's fourth seed Kei Nishikori wipe past American Donald Young 6-2 6-4, while on the other side of the draw Spanish 21st seed Pablo Carreno Busta and Argentine 27th seed Pablo Cuevas make once away to the quarters.
American 17th seed Jack Sock battled past Malek Jaziri of Tunisia 4-6 7-6 (7-1) 7-5.
Austrian eighth seed Dominic Thiem eased past France's Monfils 6-3, 6-2. Thiem will play Switzerland's Stan Wawrinka, after the three-time impressive slam champion, labored for two hours and 13 minutes to get past world number 70 Yoshihito Nishioka, winning in three sets 3-6 6-3 7-6.