England manager Gareth Southgate is awarded to experiment with a three-man defensive system and give Burnley's Michael Keane his debut in Wednesday's friendly with Germany in Dortmund.
Keane, 24, is set to begin alongside captain Gary Cahill and Chris Smalling, with John Stones, fixed to return for Sunday's home World Cup qualifier with Lithuania when Cahill is deterred.
West Bromwich Albion midfielder Jake Livermore is also awaiting to start in his first England aspect since a friendly with Italy in August 2012.
England (expected): Hart; Keane, Smalling Cahill; Walker, Dier, Bertrand; Lallana, Livermore, Alli, Vardy.
Ahead Raheem Sterling missed training on Tuesday, while Southgate has solved against calling up a replacement for hurt defender Phil Jones.
Former Arsenal attacker Lukas Podolski will captain Germany as he wins his 130th and final cap, but Mesut Ozil, Julian Draxler, Mario Gomez and Manuel Neuer are all injured.
The fixture is Southgate's first since being assigned on a permanent basis in November, following a four-game spell as caretaker which conduct two wins and two draws.
England is without decent captain Wayne Rooney against the 2014 world champions, while Harry Kane and Daniel Sturridge miss out through injury.
That leaves Vardy, Jermain Defoe and Marcus Rashford as the only strikers in Southgate's team- with Vardy set to be supported by attacking midfielders Adam Lallana and Dele Alli against Germany.
On Sunday, uncapped winger Michail Antonio - who has been playing in an advanced role for West Ham - withdrew of a hamstring injury.
The trip to Germany is come after on Sunday by a World Cup qualifier against Lithuania at Wembley.
Speaking about Sterling's fitness interest, Southgate said: "I've got to balance what is right for Wednesday and what is right for Sunday as well, so we'll keep monitoring that.
With Cahill missing the Lithuania match at Wembley as of suspension, Southgate said he would contempt whether to add an extra defender to provide cover for when the squad return to England.